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Home of the Parkinson's Improvement Programme

We are glad to share the views of people who find this programme helpful. Please send in your thoughts as to any effect the Programme has had for you. There are now over one hundred known and twenty current participants in the UK

A Big Thank You to all those who have taken part up to now

A VERY BIG THANK YOU for donations to the programme. This continues to help fund supplies for several participants. Also a thank you to Higher Nature for the continued supply of lemon flavoured fish oil at a reduced price. This kind of help is wonderful. The programme costs the PIP charity about £3,000 per year at present. In order to facilitate the raising of funds to continue the Programme it has been registered with the Charity Commissioners. We are charity no: 1137081. All donations should be made payable to the ‘Parkinson’s Improvement Programme’ – thank you

Parkinson’s Improvement Programme is also registered for Gift Aid recovery of tax on donations. You can give through www.justgiving.com or directly by cheque to 27 Newton Road, Ashton, Preston, United Kingdom, PR2 1DY

It was disappointing to receive a letter from a local consultant saying that he saw no value in early or any use of food additives and supplements and advised all newly diagnosed PwP to start a drug regime based on the Schapira-Obeso hypothesis. It recommends dopamine agonists which many PwP consider to be the cause of their hypersexuality, compulsive gambling and/or obsessive behaviour. Side effects of these types are not uncommon and are the subject of a proposed PDS research project as well as ongoing court proceedings. You may wish to look at the many entries in the ‘Compulsive behaviour’ thread on the PDS Forum www.parkinsons.org.uk/forum

Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production

From the journal ‘Brain, Behavior and Immunity’

Our thanks to them for permission to publish this work which complements our findings that adjustment of gut conditions can greatly improve brain dysfunction.

Abstract of article

Intestinal microbiota are critical for health with changes associated with diverse human diseases. Research suggests altered intestinal microbiota can profoundly affect brain function. However, whether altering brain function directly affects the microbiota is unknown. Since it is currently unclear how brain injury induces clinical complications such as infections or paralytic ileus, key contributors to prolonged hospitalization and death post-stroke, we tested in mice the hypothesis that brain damage induced changes in the intestinal microbiota. Experimental stroke altered the composition of caecal microbiota, with specific changes in Peptococcaceae and Prevotellaceace correlating with the extent of injury. These effects are mediated by noradrenaline release from the autonomic nervous system with altered caecal mucoprotein production and goblet cell numbers. Traumatic brain injury also caused changes in the gut microbiota, confirming brain injury effects gut microbiota. Changes in intestinal microbiota after brain injury may affect recovery and treatment of patients should appreciate such changes.

The complete article can be found at :

doi:10.1016/j.bbi.2016.04.003

Survey

HOORAY!!!

Parkinson’sUK – the biggest Parkinson’s charity – is asking for outcomes of people taking supplements. PIPmix users can now officially tell P UK how good PIPmix is for them; how it helps combat depression, improves writing and speech, gives them their smile back, fixes constipation, makes walking easier.

Check out www.parkinsons.org.uk/repurposingsurvey and let them know how good PIPmix is for you – THANK YOU

Rheumatoid arthritis

References of interest

From Nature Medicine 5th August 2015

  • Germs and joints: the contribution of the human microbiome to rheumatoid arthritis pp839 – 841
    Geraint B Rogers
    doi:10.1038/nm.3916

    Rheumatoid arthritis (RA) is a debilitating autoimmune disorder, the etiology of which is poorly understood. A new study reveals dysbiosis in gut and oral microbiomes of affected individuals, potentially providing a basis for patient stratification and clues to pathophysiological mechanisms of RA onset and progression.

  • The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment pp895 – 905
    Xuan Zhang, Dongya Zhang, Huijue Jia, Qiang Feng, Donghui Wang et al.
    doi:10.1038/nm.3914

    The gut and oral microbiomes are altered in individuals with rheumatoid arthritis, and these changes can be used to stratify individuals for diagnostic and prognostic purposes.

Trigeminal neuralgia

Find some startling news of a possible treatment for this desperately painful condition. Look in the articles section of this site and scroll down

Palmitoyl ascorbate and cancer

Palmitoyl ascorbate (PA) is a strong anti-oxidant, is anti-angiogenic (reduces the formation of new blood vessels) and is the lipid-soluble form of Vitamin C. There are many ways these properties are useful and it is likely that PA can be useful in combatting all cancers. The article ‘Acylhomoserine lactone’ on this site explains in more detail its action as it builds up the ascorbate concentration in the host cells to combat invasive tumours. The effect of reduction in the formation of new blood vessels by an active tumour is also useful in slowing tumour development.

Recent work with cell cultures at the University of Central Lancashire has shown that palmitoyl ascorbate can wipe out glioblastoma cells in vitro. Glioblastoma is the most aggressive form of brain tumour and often found in young children. If this could be slowed down or stopped by a substance taken by mouth it might mean less or no surgery and a greatly improved recovery rate from this devastating condition. The work needs to be taken up by a University equipped for animal testing of the substance.

Rheumatoid arthritis

Recent experience of the use of lemon fish oil and palmitoyl ascorbate in a case of rheumatoid arthritis of some ten years standing has suggested that this might be a novel and highly effective treatment for this difficult condition.

Palmitoyl ascorbate has been in use as part of a treatment for Parkinson’s Disease for the past 8 years. It is used widely in the food industry as an anti-oxidant and we are using it at a very safe daily intake level. It has other names: Vitamin C palmitate; ascorbyl palmitate; E-304 – all the same thing.

We suggest a daily intake of 1 – 2 grammes (a heaped teaspoonful) together with 5 ml of Lemon fish oil.

Palmitoyl ascorbate is lipid-soluble whereas Vitamin C (ascorbic acid) is water soluble. This difference in solubility enables this compound to be more effective in some situations than natural Vitamin C. For example, in laboratory conditions it is 100 % lethal to Helicobacter pylori – a nasty stomach dwelling bug.

The mechanism of action of Lemon fish oil and palmitoyl ascorbate in rheumatoid arthritis is not known although it seems likely to be some combination of antibacterial activity together with some damping down of chronic inflammation.