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Home of the Parkinson's Improvement Programme

Apparent regression of symptoms of Alzheimer’s – a case report

An 80 year old male retired for 15 years from a career as a research chemist began to show symptoms of loss of memory and aimless activity. Over a period of 15 months his condition deteriorated and in 2016 a diagnosis of vascular dementia was reached for which no treatment was offered. Eight months later he was detached from reality to the extent of not knowing his wife or family, wandering the streets looking for his house although he lived with his wife in the house they had occupied for 50 years and becoming aggressive because of frustration and what he saw as unhelpful but unknown people around him.
In July 2017 he began a daily oral intake of PIPmix – a mixture of fish and other oils, food additives and supplements* – which has been found to have disease modifying function in cases of Parkinson’s disease. This reduced the psychosis and aggression but still left the other symptoms unabated.
In October 2017 the diagnosis was changed to Alzheimer’s and he was put on Donepezil (Aricept) 20mg daily. This resulted in an improvement in memory and function and a reduction in the frustration he felt.
In November 2017 he started to take a modified PIPmix** which had baicalein extract added. Baicalein has the property of slowing or stopping formation of amyloid in neurons (ref).
From that point onwards progress was rapid and continues to date. He is now able to recognise and communicate meaningfully with his family, neighbours and professional attendants. He can hold a conversation for an hour. He attempts crosswords and other word puzzles.
He reads books, remembers holidays and events, discusses his former hobbies and occupation and in almost every way is restored to normal. He has been able to walk half a mile unaccompanied to local shops to purchase various items and this includes crossing roads and negotiating junctions thus proving he remembers the routes.
Most notable is the return of both long and short term memory over a wide range of subjects indicating little or no loss of neurons beyond normal age changes. It has been likened to the gradual re-opening of a reference library.
It is not usual for Donepezil or other acetylcholinesterase inhibitors to result in such an improvement in a short time and it must be concluded that the combination of two treatments is the cause of such a dramatic outcome.
Further research with other cases is in progress.
*
PIPmix comprises (30 days supply):

Palmitoyl Ascorbate 75gm
EV olive oil 15ml
EV rapeseed oil 90ml
Lemon fish oil 175ml
Organic coconut oil 60ml

**
PIPmix modified (30 day supply):

Above amounts plus

Baicalein extract 150gm

References
Donepezil in Alzheimer’s disease: From conventional trials to pharmacogenetics
Ramón Cacabelos
Neuropsychiatr Dis Treat. 2007 Jun; 3(3): 303–333.

Palop JJ, Mucke L (2016) Network abnormalities and interneuron

dysfunction in Alzheimer disease. Nat Rev Neurosci 17:777–792.

Surgery for Trigeminal Neuralgia

 

·  An improved microvascular decompression in treating trigeminal neuralgia: application of nest-shaped Teflon fibers

Original Research Article

  • World Neurosurgery        Available online 28 September 2017
  • Yingbin Jiao, Zhiyong Yan, Shusheng Che, Chao Wang, Jianpeng Wang, Xin Wang, He Wang, Weiguo Qi, Yugong Feng

 

Abstract

The aim of this study was to develop an improved Microvascular decompression (MVD) surgery using nest-shaped Teflon fibers. Eighteen consecutive trigeminal neuralgia (TN) patients who underwent MVD using nest-shaped Teflon fibers between January 2012 and December 2013 were included in this investigation. During the surgery, the nest shape of Teflon was formed by gently pushing Teflon prosthesis at the center position toward the periphery. Immediate postoperative outcome was evaluated using numerical rating scale (NRS) score, then patients were followed up for recurrence. Pain was completely relieved in 16 (88.9%) cases immediately after the surgery, and 2 cases (11.1%) achieved partial pain relief. Seven (38.9%) patients developed postoperative complications. All complications were successfully mitigated before discharge. The patients were followed up for 2.0 to 3.4 years. During follow-up, recurrence was observed in 2 patient (11.1%). No Teflon adhesion or Teflon-induced granuloma was found. The nest-shaped Teflon fibers in MVD surgery for TN is safe and applicable. The long-term outcomes and the comparison between hollow nest-shaped implants and the standard cigar-shaped implants should be assessed in the future investigation with a large sample size.

 

 

 

News

NEW !

After much trial we have reformulated PIPmix – the PD tonic so it should be more effective in more cases.

The new formulation for a 40 day supply of PIPmix N is:

Palmitoyl Ascorbate    93gm

Trehalose                    93gm

EV olive oil                   20ml

EV rapeseed oil            78ml

Lemon fish oil             200ml

 

This is taken as one dose of 10 ml (a dessertspoonful) or twice daily as 5ml (a teaspoonful). Some users find the twice daily regime gives longer lasting results.

 

For holiday use Palmitoyl ascorbate (aka. E-304 or ascorbyl palmitate) can be supplied in sachets of powder each 2.4gm – the daily intake of the main ingredient in PIPmix. This is acceptable at airports and is sufficient to maintain the PIPmix effect for the duration of the holiday.

 

PIPmix is supplied free of charge to trial participants.

News

NEWS
E-304 (aka. Palmitoyl ascorbate or ascorbyl palmitate) is to be used in a clinical trial as a remedy for the intractable pain of Trigeminal Neuralgia (TN). Up to now it has shown itself to be a 100% success even in cases where there has been TN pain for 30 years or more. There are no other remedies anywhere near so successful and most have unpleasant side-effects. In due course savings to the NHS will be in the order of tens of millions of £ per year.

Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production

From the journal ‘Brain, Behavior and Immunity’

Our thanks to them for permission to publish this work which complements our findings that adjustment of gut conditions can greatly improve brain dysfunction.

Abstract of article

Intestinal microbiota are critical for health with changes associated with diverse human diseases. Research suggests altered intestinal microbiota can profoundly affect brain function. However, whether altering brain function directly affects the microbiota is unknown. Since it is currently unclear how brain injury induces clinical complications such as infections or paralytic ileus, key contributors to prolonged hospitalization and death post-stroke, we tested in mice the hypothesis that brain damage induced changes in the intestinal microbiota. Experimental stroke altered the composition of caecal microbiota, with specific changes in Peptococcaceae and Prevotellaceace correlating with the extent of injury. These effects are mediated by noradrenaline release from the autonomic nervous system with altered caecal mucoprotein production and goblet cell numbers. Traumatic brain injury also caused changes in the gut microbiota, confirming brain injury effects gut microbiota. Changes in intestinal microbiota after brain injury may affect recovery and treatment of patients should appreciate such changes.

The complete article can be found at :

doi:10.1016/j.bbi.2016.04.003

Rheumatoid arthritis

References of interest

From Nature Medicine 5th August 2015

  • Germs and joints: the contribution of the human microbiome to rheumatoid arthritis pp839 – 841
    Geraint B Rogers
    doi:10.1038/nm.3916

    Rheumatoid arthritis (RA) is a debilitating autoimmune disorder, the etiology of which is poorly understood. A new study reveals dysbiosis in gut and oral microbiomes of affected individuals, potentially providing a basis for patient stratification and clues to pathophysiological mechanisms of RA onset and progression.

  • The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment pp895 – 905
    Xuan Zhang, Dongya Zhang, Huijue Jia, Qiang Feng, Donghui Wang et al.
    doi:10.1038/nm.3914

    The gut and oral microbiomes are altered in individuals with rheumatoid arthritis, and these changes can be used to stratify individuals for diagnostic and prognostic purposes.

Trigeminal neuralgia

Find some startling news of a possible treatment for this desperately painful condition. Look in the articles section of this site and scroll down

Palmitoyl ascorbate and cancer

Palmitoyl ascorbate (PA) is a strong anti-oxidant, is anti-angiogenic (reduces the formation of new blood vessels) and is the lipid-soluble form of Vitamin C. There are many ways these properties are useful and it is likely that PA can be useful in combatting all cancers. The article ‘Acylhomoserine lactone’ on this site explains in more detail its action as it builds up the ascorbate concentration in the host cells to combat invasive tumours. The effect of reduction in the formation of new blood vessels by an active tumour is also useful in slowing tumour development.

Recent work with cell cultures at the University of Central Lancashire has shown that palmitoyl ascorbate can wipe out glioblastoma cells in vitro. Glioblastoma is the most aggressive form of brain tumour and often found in young children. If this could be slowed down or stopped by a substance taken by mouth it might mean less or no surgery and a greatly improved recovery rate from this devastating condition. The work needs to be taken up by a University equipped for animal testing of the substance.

Rheumatoid arthritis

Recent experience of the use of lemon fish oil and palmitoyl ascorbate in a case of rheumatoid arthritis of some ten years standing has suggested that this might be a novel and highly effective treatment for this difficult condition.

Palmitoyl ascorbate has been in use as part of a treatment for Parkinson’s Disease for the past 8 years. It is used widely in the food industry as an anti-oxidant and we are using it at a very safe daily intake level. It has other names: Vitamin C palmitate; ascorbyl palmitate; E-304 – all the same thing.

We suggest a daily intake of 1 – 2 grammes (a heaped teaspoonful) together with 5 ml of Lemon fish oil.

Palmitoyl ascorbate is lipid-soluble whereas Vitamin C (ascorbic acid) is water soluble. This difference in solubility enables this compound to be more effective in some situations than natural Vitamin C. For example, in laboratory conditions it is 100 % lethal to Helicobacter pylori – a nasty stomach dwelling bug.

The mechanism of action of Lemon fish oil and palmitoyl ascorbate in rheumatoid arthritis is not known although it seems likely to be some combination of antibacterial activity together with some damping down of chronic inflammation.