Archive for April, 2016

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Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production

From the journal ‘Brain, Behavior and Immunity’

Our thanks to them for permission to publish this work which complements our findings that adjustment of gut conditions can greatly improve brain dysfunction.

Abstract of article

Intestinal microbiota are critical for health with changes associated with diverse human diseases. Research suggests altered intestinal microbiota can profoundly affect brain function. However, whether altering brain function directly affects the microbiota is unknown. Since it is currently unclear how brain injury induces clinical complications such as infections or paralytic ileus, key contributors to prolonged hospitalization and death post-stroke, we tested in mice the hypothesis that brain damage induced changes in the intestinal microbiota. Experimental stroke altered the composition of caecal microbiota, with specific changes in Peptococcaceae and Prevotellaceace correlating with the extent of injury. These effects are mediated by noradrenaline release from the autonomic nervous system with altered caecal mucoprotein production and goblet cell numbers. Traumatic brain injury also caused changes in the gut microbiota, confirming brain injury effects gut microbiota. Changes in intestinal microbiota after brain injury may affect recovery and treatment of patients should appreciate such changes.

The complete article can be found at :